If I read the specifications of your machine correctly, you have quite some options to make use of your slot.
Sound: Your onboard sound is a SigmaTel STAC9200. So installing an Audigy 2 ZS Notebook will probably be a nice improvment in the sound department, supporting even EAX 4.0.
Graphics: You have the chipset based GMA 950 and a dedicated Quadro NVS 110M, which is similar to a Geforce Go 7300. Whether a VTbook card will be an upgrade to the Quadro I doubt it.
You might have a look at the eGPU "GDC Beast", which is also available for the PC Card slot. The potential gain depends on the graphics card you would install in the extension. Please note that it might require some fiddling to get it work, but the potential improvement might be worth it.
Another alternative is to look for the big docking station from Dell "D/Dock" (PD01X), which is available for your laptop and has an internal slot for a PCI (graphics) card. You will be a bit limited with size and power consumption of the card, but it is way more compact and clean then the eGPU variant. You might consider a ZOTAC Geforce GT610 which from time to time crop up in the PCI version. On AMD side you might check for the HD5450 (available from HIS and Club3D). There are more, but not as powerful then the aforementioned. Anyhow, as the interface is only PCI it will limit the potential gain to some extent. Your internal Quadro is connected via PCI Express Gen 1, so here the limit will be rather the card itself, not supporting the higher video engines and directx versions.
Network: your laptop already has a Gb network, so probably not much improvement to be gained with a new network card
USB: I am not sure if an additional USB 3.0 card will be fully utilized in your card slot, but might be an improvement anyway.
Optional: Firewire, eSATA, TV cards, CF card reader, 3G card, etc.