Error 6 is an unknown error when loading the tape. Sometimes it can be caused by dirt and a cleaning tape/new tape can fix it. Other times it is a physical fault with the loading operation.
When you put the tape in the drive is it pulled in and then loaded? You should hear it pulling the pin out of the cassette and spooling the first part of the tape onto the spool inside the drive.
Does it eject successfully? If it spooled correctly then there will be a delay as it rewinds tape back into the cassette and then places the pin back inside (it's behind the little flap on the cassette).
I usually have to swap out drives with error 6. Sometimes I take them apart to see what is jammed or if there is something stuck inside when out of warranty. FYI A warning: the drives can have delicate ribbon cables on the outside that can be sliced by the outer case when removing/closing it, the ribbon cables run all the way though the drive and cannot be replaced easily.
You can also restart most LTO drives without rebooting by pressing and holding the eject button, although software may need its services restarted to see the drive again. They do not usually recover from error 6 and need this cycle to accept instructions again.